Introduction to Bioinformatics
Chapter 9
Exercises
1. Name the two modalities of analysis following sequencing.
2. Name any three major types of variants.
3. What are disease-specific variants termed?
(a) somatic
(b) germline
4. Which is the preferred tool for transcriptome assembly, in the de novo and genome-guided modalities?
(a) Tophat2
(b) Trinity
5. What is the difference between BLAT and BLAST?
6. What came first? Structural Bioinformatics or Genome informatics?
7. Name any two of the major classes of biological macromolecules.
8. DNA sequences can be represented by which of the
following data format?
(a) FASTQ
(b) FASTA
(c) AB1
(d) All of the above
9. Can a phylogeny be produced dbhjirectly from a multi-fasta file? Justify your answer.
10. Which tool can help you visualise variants in a circular manner?
(a) UCSC Genome Browser
(b) CIRCOS
(c) IGV
11. Which of the following approaches can help one in arriving at a comprehensive understanding of the biology of an organism?
(a) Single assay across multiple individuals.
(b) Multiple orthogonal assays across fewer individuals.
12. Why do we need to sequence nucleic acids? What can one gain by understanding the sequence of nucleic acide?
Questions Type By: Himashree Bora.
